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I always say **Bless You**. I used to say **gesundheit** [used to wish good health to a person who has just sneezed.] More apt, but German is not understood much in the States anymore.

I say it. If someone gets annoyed by it that's a bonus.

Just as a fact point, it was believed, incorrectly, that when you sneezed you were close to death. People said "Bless You" as a prayer to protect the sneezer.
 
Since we know that is not true now, the idea of saying a blessing seems out of step with current knowledge.
 
Not against saying it, this is just something to know.