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Sexual activity and prostate cancer risk in men diagnosed at a younger age

https://pubmed.ncbi.nlm.nih.gov/19016689/

Abstract
Objective: To examine, in a case-control study, the association between the frequency of sexual activity (intercourse, masturbation, overall) and prostate cancer risk in younger men diagnosed at < or = 60 years old.

Patients, subjects and methods: In all, 431 prostate cancer cases and 409 controls participated and provided information on their sexual activity. In particular, the frequencies of intercourse and masturbation during the participants' different age decades (20s, 30s, 40s, 50s) were collected.

Results: Whereas frequent overall sexual activity in younger life (20s) increased the disease risk, it appeared to be protective against the disease when older (50s). Alone, frequent masturbation activity was a marker for increased risk in the 20s and 30s but appeared to be associated with a decreased risk in the 50s, while intercourse activity alone was not associated with the disease.

Conclusion: These findings could imply different mechanisms by which sexual activity is involved in the aetiology of prostate cancer at different ages. Alternatively, there is a possibility of reverse causation in explaining part of the protective effect seen for men in their 50s.



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paste the doi 10.1111/j.1464-410X.2008.08030.x to https://www.sci-hub.se/ for full text

this is a snippet of it:

>"For men in their 20s, "frequent masturbation" was two to seven times per week. Compared to same-age men who reported masturbating less than once per month, 20-something frequent masturbators had a 79% higher risk of prostate cancer by age 60."